Prolonged and tunable residence time using reversible covalent kinase inhibitors
Prolonged and tunable residence time using reversible covalent kinase inhibitors
About this item
Full title
Author / Creator
Bradshaw, J Michael , McFarland, Jesse M , Paavilainen, Ville O , Bisconte, Angelina , Tam, Danny , Phan, Vernon T , Romanov, Sergei , Finkle, David , Shu, Jin , Patel, Vaishali , Ton, Tony , Li, Xiaoyan , Loughhead, David G , Nunn, Philip A , Karr, Dane E , Gerritsen, Mary E , Funk, Jens Oliver , Owens, Timothy D , Verner, Erik , Brameld, Ken A , Hill, Ronald J , Goldstein, David M and Taunton, Jack
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Structural changes in the capping groups of inverted cyanoacrylamide-based kinase inhibitors resulted in alterations in residence time, with some compounds exhibiting sustained pharmacological effects
in vivo
.
Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target res...
Alternative Titles
Full title
Prolonged and tunable residence time using reversible covalent kinase inhibitors
Authors, Artists and Contributors
Author / Creator
McFarland, Jesse M
Paavilainen, Ville O
Bisconte, Angelina
Tam, Danny
Phan, Vernon T
Romanov, Sergei
Finkle, David
Shu, Jin
Patel, Vaishali
Ton, Tony
Li, Xiaoyan
Loughhead, David G
Nunn, Philip A
Karr, Dane E
Gerritsen, Mary E
Funk, Jens Oliver
Owens, Timothy D
Verner, Erik
Brameld, Ken A
Hill, Ronald J
Goldstein, David M
Taunton, Jack
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4472506
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4472506
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1817
