Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Here we show that TLR3 binding to dsRNA promotes post-translational inflammasome activation through intermediate and late TRI...
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Full title
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4480782
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4480782
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8515
