Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Rapidly proliferating tissues, including human tumors, use PDH to generate energy and macromolecular precursors. However, evidence supports t...
Alternative Titles
Full title
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4487196
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4487196
Other Identifiers
ISSN
2049-3002
E-ISSN
2049-3002
DOI
10.1186/s40170-015-0134-4
