Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
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Publisher
Washington: American Association for the Advancement of Science
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English
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Washington: American Association for the Advancement of Science
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Contents
Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation have revealed the basis of much of our understanding of heterochromatin. We took an analogous approach to identify genes required for epigenetic repression in human cells. A nonlethal forward genetic screen in near-haploid KBM7 cells identified the HUSH...
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Full title
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4487827
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4487827
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaa7227
