Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte devel...
Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development
About this item
Full title
Author / Creator
Mishima, Yuta , Wang, Changshan , Miyagi, Satoru , Saraya, Atsunori , Hosokawa, Hiroyuki , Mochizuki-Kashio, Makiko , Nakajima-Takagi, Yaeko , Koide, Shuhei , Negishi, Masamitsu , Sashida, Goro , Naito, Taku , Ishikura, Tomoyuki , Onodera, Atsushi , Nakayama, Toshinori , Tenen, Daniel G. , Yamaguchi, Naoto , Koseki, Haruhiko , Taniuchi, Ichiro and Iwama, Atsushi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
During T-cell development,
Cd8
expression is controlled via dynamic regulation of its
cis
-regulatory enhancer elements. Insufficiency of enhancer activity causes variegated
Cd8
expression in CD4
+
CD8
+
double-positive (DP) thymocytes. Brd1 is a subunit of the Hbo1 histone acetyltransferase (HAT) complex responsible f...
Alternative Titles
Full title
Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development
Authors, Artists and Contributors
Author / Creator
Wang, Changshan
Miyagi, Satoru
Saraya, Atsunori
Hosokawa, Hiroyuki
Mochizuki-Kashio, Makiko
Nakajima-Takagi, Yaeko
Koide, Shuhei
Negishi, Masamitsu
Sashida, Goro
Naito, Taku
Ishikura, Tomoyuki
Onodera, Atsushi
Nakayama, Toshinori
Tenen, Daniel G.
Yamaguchi, Naoto
Koseki, Haruhiko
Taniuchi, Ichiro
Iwama, Atsushi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4490789
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4490789
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6872
