Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutr...
Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies
About this item
Full title
Author / Creator
Pritchard, Laura K. , Spencer, Daniel I.R. , Royle, Louise , Bonomelli, Camille , Seabright, Gemma E. , Behrens, Anna-Janina , Kulp, Daniel W. , Menis, Sergey , Krumm, Stefanie A. , Dunlop, D. Cameron , Crispin, Daniel J. , Bowden, Thomas A. , Scanlan, Christopher N. , Ward, Andrew B. , Schief, William R. , Doores, Katie J. and Crispin, Max
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The envelope spike of HIV-1 employs a ‘glycan shield’ to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly neutralizing antibodies (bnAbs) that target this shield have been isolated. The unusually high glycan density on the gp120 subunit limits processing during biosynthesis, leaving a region of under-proc...
Alternative Titles
Full title
Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies
Authors, Artists and Contributors
Author / Creator
Spencer, Daniel I.R.
Royle, Louise
Bonomelli, Camille
Seabright, Gemma E.
Behrens, Anna-Janina
Kulp, Daniel W.
Menis, Sergey
Krumm, Stefanie A.
Dunlop, D. Cameron
Crispin, Daniel J.
Bowden, Thomas A.
Scanlan, Christopher N.
Ward, Andrew B.
Schief, William R.
Doores, Katie J.
Crispin, Max
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4500839
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4500839
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8479
