Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular localization.
Here we demonstrate that the accumulation of Tks4(R43W) depends on the intact microtubule network. Detergent-insoluble Tks4...
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Full title
Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4504077
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4504077
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ISSN
1478-811X
E-ISSN
1478-811X
DOI
10.1186/s12964-015-0108-8
