Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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United States: American Association for the Advancement of Science
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Contents
Histone H3 lysine27-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes...
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Full title
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4508193
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4508193
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1255104
