Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
About this item
Full title
Author / Creator
Grebien, Florian , Vedadi, Masoud , Getlik, Matthäus , Giambruno, Roberto , Grover, Amit , Avellino, Roberto , Skucha, Anna , Vittori, Sarah , Kuznetsova, Ekaterina , Smil, David , Barsyte-Lovejoy, Dalia , Li, Fengling , Poda, Gennadiy , Schapira, Matthieu , Wu, Hong , Dong, Aiping , Senisterra, Guillermo , Stukalov, Alexey , Huber, Kilian V M , Schönegger, Andreas , Marcellus, Richard , Bilban, Martin , Bock, Christoph , Brown, Peter J , Zuber, Johannes , Bennett, Keiryn L , Al-awar, Rima , Delwel, Ruud , Nerlov, Claus , Arrowsmith, Cheryl H and Superti-Furga, Giulio
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The p30 isoform of C/EBPα associated with leukemia interacts with WDR5, a component of the SET/MLL histone methyltransferase complex. A small molecule, OICR-9429, disrupted p30-WDR5 interactions, resulting in differentiation of p30-expressing leukemia cells.
The
CEBPA
gene is mutated in 9% of patients with acute myeloid leukemia (AML). Sel...
Alternative Titles
Full title
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
Authors, Artists and Contributors
Author / Creator
Vedadi, Masoud
Getlik, Matthäus
Giambruno, Roberto
Grover, Amit
Avellino, Roberto
Skucha, Anna
Vittori, Sarah
Kuznetsova, Ekaterina
Smil, David
Barsyte-Lovejoy, Dalia
Li, Fengling
Poda, Gennadiy
Schapira, Matthieu
Wu, Hong
Dong, Aiping
Senisterra, Guillermo
Stukalov, Alexey
Huber, Kilian V M
Schönegger, Andreas
Marcellus, Richard
Bilban, Martin
Bock, Christoph
Brown, Peter J
Zuber, Johannes
Bennett, Keiryn L
Al-awar, Rima
Delwel, Ruud
Nerlov, Claus
Arrowsmith, Cheryl H
Superti-Furga, Giulio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4511833
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4511833
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1859
