Structural prerequisites for G-protein activation by the neurotensin receptor
Structural prerequisites for G-protein activation by the neurotensin receptor
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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We previously determined the structure of neurotensin receptor NTSR1 in an active-like conformation with six thermostabilizing mutations bound to the peptide agonist neurotensin. This receptor was unable to activate G proteins, indicating that the mutations restricted NTSR1 to relate agonist binding to G-protein activation. Here we analyse the effe...
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Full title
Structural prerequisites for G-protein activation by the neurotensin receptor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4515772
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4515772
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8895
