PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutati...
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Full title
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4518267
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4518267
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8769
