Brain feminization requires active repression of masculinization via DNA methylation
Brain feminization requires active repression of masculinization via DNA methylation
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Hormone-induced brain masculinization occurs during a perinatal sensitive period but endures into adulthood. Researchers explored DNA methylation as a candidate mechanism. Methylation is higher in female brain and suppresses masculinization genes, which are liberated by hormone-induced reductions in DNMT activity in males. Pharmacological inhibitio...
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Full title
Brain feminization requires active repression of masculinization via DNA methylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4519828
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4519828
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3988
