Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylchol...
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist
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Author / Creator
Luo, Sulan , Zhangsun, Dongting , Harvey, Peta J. , Kaas, Quentin , Wu, Yong , Zhu, Xiaopeng , Hu, Yuanyan , Li, Xiaodan , Tsetlin, Victor I. , (Цетлин) , Christensen, Sean , Romero, Haylie K. , McIntyre, Melissa , Dowell, Cheryl , Baxter, James C. , Elmslie, Keith S. , Craik, David J. and McIntosh, J. Michael
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
We identified a previously unidentified conotoxin gene fromConus generaliswhose precursor signal sequence has high similarity to the O1-gene conotoxin superfamily. The predicted mature peptide, αO-conotoxin GeXIVA (GeXIVA), has four Cys residues, and its three disulfide isomers were synthesized. Previously pharmacologically characterized O1-superfa...
Alternative Titles
Full title
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4522777
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4522777
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1503617112
