CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2
CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Nrf2 is the pre-dominant transcription activator responsible for coordinated up-regulation of ARE-driven antioxidant and detoxification genes. The activity of Nrf2 is tightly regulated at basal levels through its ubiquitination by Cul3-Keap1 and consequential degradation. Upon exposure to stress, the Cul3-Keap1 ligase is inhibited, leading to Nrf2...
Alternative Titles
Full title
CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4523873
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4523873
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep12857
