The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
About this item
Full title
Author / Creator
Zhu, Yi , Tchkonia, Tamara , Pirtskhalava, Tamar , Gower, Adam C. , Ding, Husheng , Giorgadze, Nino , Palmer, Allyson K. , Ikeno, Yuji , Hubbard, Gene B. , Lenburg, Marc , O'Hara, Steven P. , LaRusso, Nicholas F. , Miller, Jordan D. , Roos, Carolyn M. , Verzosa, Grace C. , LeBrasseur, Nathan K. , Wren, Jonathan D. , Farr, Joshua N. , Khosla, Sundeep , Stout, Michael B. , McGowan, Sara J. , Fuhrmann‐Stroissnigg, Heike , Gurkar, Aditi U. , Zhao, Jing , Colangelo, Debora , Dorronsoro, Akaitz , Ling, Yuan Yuan , Barghouthy, Amira S. , Navarro, Diana C. , Sano, Tokio , Robbins, Paul D. , Niedernhofer, Laura J. and Kirkland, James L.
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
England: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Summary
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age‐related chronic diseases. Here, we describe the rationale for identification and validation of a new class of drugs termed senolyti...
Alternative Titles
Full title
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Authors, Artists and Contributors
Author / Creator
Tchkonia, Tamara
Pirtskhalava, Tamar
Gower, Adam C.
Ding, Husheng
Giorgadze, Nino
Palmer, Allyson K.
Ikeno, Yuji
Hubbard, Gene B.
Lenburg, Marc
O'Hara, Steven P.
LaRusso, Nicholas F.
Miller, Jordan D.
Roos, Carolyn M.
Verzosa, Grace C.
LeBrasseur, Nathan K.
Wren, Jonathan D.
Farr, Joshua N.
Khosla, Sundeep
Stout, Michael B.
McGowan, Sara J.
Fuhrmann‐Stroissnigg, Heike
Gurkar, Aditi U.
Zhao, Jing
Colangelo, Debora
Dorronsoro, Akaitz
Ling, Yuan Yuan
Barghouthy, Amira S.
Navarro, Diana C.
Sano, Tokio
Robbins, Paul D.
Niedernhofer, Laura J.
Kirkland, James L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531078
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531078
Other Identifiers
ISSN
1474-9718
E-ISSN
1474-9726
DOI
10.1111/acel.12344
