ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent ma...
ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Urinary tract infections (UTIs) are frequent, commonly recurrent, and costly. Deficiency in a key autophagy protein, ATG16L1, protects mice from infection with the predominant bacterial cause of UTIs, Uropathogenic
E. coli
(UPEC). Here, we report that loss of ATG16L1 in macrophages accounts for this protective phenotype. Compared with wild-ty...
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Full title
ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4532666
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4532666
Other Identifiers
ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/mi.2015.7
