Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition
Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
A Kv1 channel inhibitor and potential therapeutic lead achieves selectivity by binding both the conserved central cavity and newly identified side pockets, which provide the key determinants for channel specificity.
Most known small-molecule inhibitors of voltage-gated ion channels have poor subtype specificity because they interact with a highl...
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Full title
Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4539245
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4539245
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1271
