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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is suffi...

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is suffi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4539301

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

About this item

Full title

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Publisher

London: Nature Publishing Group UK

Journal title

Molecular psychiatry, 2015-11, Vol.20 (11), p.1339-1349

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer’s disease through the antagonism of adenosine A
2A
receptors (A
2A
Rs). To test if A
2A
R activation in the hippocampus is actually sufficient to impair memory function and to begin elucidating the intracell...

Alternative Titles

Full title

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4539301

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4539301

Other Identifiers

ISSN

1359-4184

E-ISSN

1476-5578

DOI

10.1038/mp.2014.182

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