Detection of sharing by descent, long-range phasing and haplotype imputation
Detection of sharing by descent, long-range phasing and haplotype imputation
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Author / Creator
Kong, Augustine , Masson, Gisli , Frigge, Michael L , Gylfason, Arnaldur , Zusmanovich, Pasha , Thorleifsson, Gudmar , Olason, Pall I , Ingason, Andres , Steinberg, Stacy , Rafnar, Thorunn , Sulem, Patrick , Mouy, Magali , Jonsson, Frosti , Thorsteinsdottir, Unnur , Gudbjartsson, Daniel F , Stefansson, Hreinn and Stefansson, Kari
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Augustine Kong and colleagues describe an approach for phasing SNPs into long haplotypes spanning multiple blocks of linkage disequilibrium. The method, termed long-range phasing, can be also used to impute long haplotypes for ungenotyped individuals.
Uncertainty about the phase of strings of SNPs creates complications in genetic analysis, altho...
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Full title
Detection of sharing by descent, long-range phasing and haplotype imputation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4540081
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4540081
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.216
