Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
About this item
Full title
Author / Creator
Simon, Christian M. , Rauskolb, Stefanie , Gunnersen, Jennifer M. , Holtmann, Bettina , Drepper, Carsten , Dombert, Benjamin , Braga, Massimiliano , Wiese, Stefan , Jablonka, Sibylle , Pühringer, Dirk , Zielasek, Jürgen , Hoeflich, Andreas , Silani, Vincenzo , Wolf, Eckhard , Kneitz, Susanne , Sommer, Claudia , Toyka, Klaus V. and Sendtner, Michael
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication in diabetes. The underlying cellular mechanisms of axon degeneration are poorly understood. IGFBP5, an inhibitory binding protein for insulin-like growth factor 1 (IGF1) is highly up-regulated in nerve biopsies of patients with DNP. We investigated the pat...
Alternative Titles
Full title
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
Authors, Artists and Contributors
Author / Creator
Rauskolb, Stefanie
Gunnersen, Jennifer M.
Holtmann, Bettina
Drepper, Carsten
Dombert, Benjamin
Braga, Massimiliano
Wiese, Stefan
Jablonka, Sibylle
Pühringer, Dirk
Zielasek, Jürgen
Hoeflich, Andreas
Silani, Vincenzo
Wolf, Eckhard
Kneitz, Susanne
Sommer, Claudia
Toyka, Klaus V.
Sendtner, Michael
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4541707
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4541707
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-015-1446-8
