SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming gr...
SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1
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Author / Creator
Publisher
England: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
England: John Wiley & Sons, Ltd
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Scope and Contents
Contents
In diabetes, hyperglycaemia causes up‐regulation of endothelin 1 (ET‐1) and transforming growth factor beta 1 (TGF‐β1). Previously we showed glucose reduces sirtuin1 (SIRT1), a class III histone deacetylase. Here, we investigated the regulatory role of SIRT1 on ET‐1 and TGF‐β1 expression. Human microvascular endothelial cells were examined followin...
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Full title
SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4549036
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4549036
Other Identifiers
ISSN
1582-1838
E-ISSN
1582-4934
DOI
10.1111/jcmm.12557
