Lentivirus-induced ‘Smart’ dendritic cells: Pharmacodynamics and GMP-compliant production for immuno...
Lentivirus-induced ‘Smart’ dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma
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Author / Creator
Sundarasetty, B S , Chan, L , Darling, D , Giunti, G , Farzaneh, F , Schenck, F , Naundorf, S , Kuehlcke, K , Ruggiero, E , Schmidt, M , von Kalle, C , Rothe, M , Hoon, D S B , Gerasch, L , Figueiredo, C , Koehl, U , Blasczyk, R , Gutzmer, R and Stripecke, R
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Monocyte-derived conventional dendritic cells (ConvDCs) loaded with melanoma antigens showed modest responses in clinical trials. Efficacy studies were hampered by difficulties in ConvDC manufacturing and low potency. Overcoming these issues, we demonstrated higher potency of lentiviral vector (LV)-programmed DCs. Monocytes were directly induced to...
Alternative Titles
Full title
Lentivirus-induced ‘Smart’ dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4561294
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4561294
Other Identifiers
ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/gt.2015.43
