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Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle ent...

Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle ent...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4572847

Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry

About this item

Full title

Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry

Publisher

American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2015-05, Vol.348 (6238), p.1024-1027

Language

English

Formats

Publication information

Publisher

American Association for the Advancement of Science

More information

Scope and Contents

Contents

Mechanical strain regulates the development organization, and function of multicellular tissues, but mechanisms linking mechanical strain and cell-cell junction proteins to cellular responses are poorly understood. Here, we showed that mechanical strain applied to quiescent epithelial cells induced rapid cell cycle reentry, mediated by independent...

Alternative Titles

Full title

Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4572847

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4572847

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aaa4559

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