Targeted Disruption of the β2‐Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Ste...
Targeted Disruption of the β2‐Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells
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Publisher
Durham, NC, USA: AlphaMed Press
Journal title
Language
English
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Publisher
Durham, NC, USA: AlphaMed Press
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Scope and Contents
Contents
It was hypothesized that transplanting human embryonic stem cells (hESCs) lacking human leukocyte antigen class I (HLA‐I) expression would not result in a robust immune rejection by allogeneic recipients. β2‐Microglobulin‐null hESCs transplanted into natural killer cell‐depleted immunocompetent mice developed tumors resembling those from control hE...
Alternative Titles
Full title
Targeted Disruption of the β2‐Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4572902
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4572902
Other Identifiers
ISSN
2157-6564
E-ISSN
2157-6580
DOI
10.5966/sctm.2015-0049
