Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching
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Full title
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
High-throughput genome-wide sequencing reveals why class switch recombination in the IgH locus, an essential step in the process of antibody generation, has a directional joining bias towards deletion rather than inversion.
Orientation-specific DNA joining
The process of antibody generation requires rearrangements in the immunoglobulin heavy...
Alternative Titles
Full title
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4592165
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4592165
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14970
