eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription
About this item
Full title
Author / Creator
Brina, Daniela , Miluzio, Annarita , Ricciardi, Sara , Clarke, Kim , Davidsen, Peter K. , Viero, Gabriella , Tebaldi, Toma , Offenhäuser, Nina , Rozman, Jan , Rathkolb, Birgit , Neschen, Susanne , Klingenspor, Martin , Wolf, Eckhard , Gailus-Durner, Valerie , Fuchs, Helmut , Hrabe de Angelis, Martin , Quattrone, Alessandro , Falciani, Francesco and Biffo, Stefano
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous for eIF6 results in normal glyca...
Alternative Titles
Full title
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription
Authors, Artists and Contributors
Author / Creator
Miluzio, Annarita
Ricciardi, Sara
Clarke, Kim
Davidsen, Peter K.
Viero, Gabriella
Tebaldi, Toma
Offenhäuser, Nina
Rozman, Jan
Rathkolb, Birgit
Neschen, Susanne
Klingenspor, Martin
Wolf, Eckhard
Gailus-Durner, Valerie
Fuchs, Helmut
Hrabe de Angelis, Martin
Quattrone, Alessandro
Falciani, Francesco
Biffo, Stefano
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4595657
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4595657
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms9261
