Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
About this item
Full title
Author / Creator
Min, Sang-Won , Chen, Xu , Tracy, Tara E , Li, Yaqiao , Zhou, Yungui , Wang, Chao , Shirakawa, Kotaro , Minami, S Sakura , Defensor, Erwin , Mok, Sue Ann , Sohn, Peter Dongmin , Schilling, Birgit , Cong, Xin , Ellerby, Lisa , Gibson, Bradford W , Johnson, Jeffrey , Krogan, Nevan , Shamloo, Mehrdad , Gestwicki, Jason , Masliah, Eliezer , Verdin, Eric and Gan, Li
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Acetylation of tau at K174 is identified in Alzheimer's disease (AD) brain tissue and exacerbates tau-mediated neurodegeneration and memory impairments in mice. Pharmacological inhibition of tau acetylation ameliorates these phenotypes in a mouse model of AD.
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are...
Alternative Titles
Full title
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Authors, Artists and Contributors
Author / Creator
Chen, Xu
Tracy, Tara E
Li, Yaqiao
Zhou, Yungui
Wang, Chao
Shirakawa, Kotaro
Minami, S Sakura
Defensor, Erwin
Mok, Sue Ann
Sohn, Peter Dongmin
Schilling, Birgit
Cong, Xin
Ellerby, Lisa
Gibson, Bradford W
Johnson, Jeffrey
Krogan, Nevan
Shamloo, Mehrdad
Gestwicki, Jason
Masliah, Eliezer
Verdin, Eric
Gan, Li
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4598295
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4598295
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3951
