Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells
About this item
Full title
Author / Creator
Ferdaoussi, Mourad , Dai, Xiaoqing , Jensen, Mette V. , Wang, Runsheng , Peterson, Brett S. , Huang, Chao , Ilkayeva, Olga , Smith, Nancy , Miller, Nathanael , Hajmrle, Catherine , Spigelman, Aliya F. , Wright, Robert C. , Plummer, Gregory , Suzuki, Kunimasa , Mackay, James P. , van de Bunt, Martijn , Gloyn, Anna L. , Ryan, Terence E. , Norquay, Lisa D. , Brosnan, M. Julia , Trimmer, Jeff K. , Rolph, Timothy P. , Kibbey, Richard G. , Manning Fox, Jocelyn E. , Colmers, William F. , Shirihai, Orian S. , Neufer, P. Darrell , Yeh, Edward T.H. , Newgard, Christopher B. and MacDonald, Patrick E.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Insulin secretion from β cells of the pancreatic islets of Langerhans controls metabolic homeostasis and is impaired in individuals with type 2 diabetes (T2D). Increases in blood glucose trigger insulin release by closing ATP-sensitive K+ channels, depolarizing β cells, and opening voltage-dependent Ca2+ channels to elicit insulin exocytosis. Howev...
Alternative Titles
Full title
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells
Authors, Artists and Contributors
Author / Creator
Dai, Xiaoqing
Jensen, Mette V.
Wang, Runsheng
Peterson, Brett S.
Huang, Chao
Ilkayeva, Olga
Smith, Nancy
Miller, Nathanael
Hajmrle, Catherine
Spigelman, Aliya F.
Wright, Robert C.
Plummer, Gregory
Suzuki, Kunimasa
Mackay, James P.
van de Bunt, Martijn
Gloyn, Anna L.
Ryan, Terence E.
Norquay, Lisa D.
Brosnan, M. Julia
Trimmer, Jeff K.
Rolph, Timothy P.
Kibbey, Richard G.
Manning Fox, Jocelyn E.
Colmers, William F.
Shirihai, Orian S.
Neufer, P. Darrell
Yeh, Edward T.H.
Newgard, Christopher B.
MacDonald, Patrick E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4607115
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4607115
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI82498
