Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner
Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner
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Author / Creator
Shi, Min , Zhang, Heng , Wang, Lantian , Zhu, Changlan , Sheng, Ke , Du, Yanhua , Wang, Ke , Dias, Anusha , Chen, She , Whitman, Malcolm , Wang, Enduo , Reed, Robin and Cheng, Hong
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that mRNAs containing any type of PTCs (UAA, UAG, and UGA) are detained in the nucleus, whereas their wild-type counterparts are rapidly exported. This retention is strictly reading-frame dependent. Strikingly...
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Full title
Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4610414
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4610414
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ISSN
2056-5968
E-ISSN
2056-5968
DOI
10.1038/celldisc.2015.1
