6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LK...
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
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Author / Creator
Lin, Ruiting , Elf, Shannon , Shan, Changliang , Kang, Hee-Bum , Ji, Quanjiang , Zhou, Lu , Hitosugi, Taro , Zhang, Liang , Zhang, Shuai , Seo, Jae Ho , Xie, Jianxin , Tucker, Meghan , Gu, Ting-Lei , Sudderth, Jessica , Jiang, Lei , Mitsche, Matthew , DeBerardinis, Ralph J. , Wu, Shaoxiong , Li, Yuancheng , Mao, Hui , Chen, Peng R. , Wang, Dongsheng , Chen, Georgia Zhuo , Hurwitz, Selwyn J. , Lonial, Sagar , Arellano, Martha L. , Khoury, Hanna J. , Khuri, Fadlo R. , Lee, Benjamin H. , Lei, Qunying , Brat, Daniel J. , Ye, Keqiang , Boggon, Titus J. , He, Chuan , Kang, Sumin , Fan, Jun and Chen, Jing
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
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Contents
The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and elevated ROS levels in cancer cells, attenuating cel...
Alternative Titles
Full title
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
Authors, Artists and Contributors
Author / Creator
Elf, Shannon
Shan, Changliang
Kang, Hee-Bum
Ji, Quanjiang
Zhou, Lu
Hitosugi, Taro
Zhang, Liang
Zhang, Shuai
Seo, Jae Ho
Xie, Jianxin
Tucker, Meghan
Gu, Ting-Lei
Sudderth, Jessica
Jiang, Lei
Mitsche, Matthew
DeBerardinis, Ralph J.
Wu, Shaoxiong
Li, Yuancheng
Mao, Hui
Chen, Peng R.
Wang, Dongsheng
Chen, Georgia Zhuo
Hurwitz, Selwyn J.
Lonial, Sagar
Arellano, Martha L.
Khoury, Hanna J.
Khuri, Fadlo R.
Lee, Benjamin H.
Lei, Qunying
Brat, Daniel J.
Ye, Keqiang
Boggon, Titus J.
He, Chuan
Kang, Sumin
Fan, Jun
Chen, Jing
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4628560
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4628560
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3255
