Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against press...
Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD
+
) biosynthesis and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD
+
by monocyte-derived extracellular Nampt (eNampt), which i...
Alternative Titles
Full title
Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4629142
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4629142
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep15857
