Structural insights into µ-opioid receptor activation
Structural insights into µ-opioid receptor activation
About this item
Full title
Author / Creator
Huang, Weijiao , Manglik, Aashish , Venkatakrishnan, A. J. , Laeremans, Toon , Feinberg, Evan N. , Sanborn, Adrian L. , Kato, Hideaki E. , Livingston, Kathryn E. , Thorsen, Thor S. , Kling, Ralf C. , Granier, Sébastien , Gmeiner, Peter , Husbands, Stephen M. , Traynor, John R. , Weis, William I. , Steyaert, Jan , Dror, Ron O. and Kobilka, Brian K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X-ray crystal structure of the murine μOR bound to the morphinan agonist BU72 and a G protein mimetic camelid antibody fragment. The BU72-stabilized changes in t...
Alternative Titles
Full title
Structural insights into µ-opioid receptor activation
Authors, Artists and Contributors
Author / Creator
Manglik, Aashish
Venkatakrishnan, A. J.
Laeremans, Toon
Feinberg, Evan N.
Sanborn, Adrian L.
Kato, Hideaki E.
Livingston, Kathryn E.
Thorsen, Thor S.
Kling, Ralf C.
Granier, Sébastien
Gmeiner, Peter
Husbands, Stephen M.
Traynor, John R.
Weis, William I.
Steyaert, Jan
Dror, Ron O.
Kobilka, Brian K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4639397
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4639397
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14886
