Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability...
Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure
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London: BioMed Central Ltd
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Language
English
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London: BioMed Central Ltd
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IntroductionPD-L1-negative tumors assessed by immunohistochemistry often still respond to PD-1 blockade. PD-L1 is inducible by interferon, therefore, absolute negative tumors are the ones unable to up-regulate PD-L1 in response to interferons. Genetic mutations in the interferon receptor signaling pathway leading to loss of PD-L1 up-regulation were...
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Full title
Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4649399
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4649399
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1186/2051-1426-3-S2-P311
