Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucl...
Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at both protein and mRNA levels. Blockade of PB decreases tumor cell growth and energy production. Additi...
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Full title
Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4657043
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4657043
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep17206
