Microenvironmental Hypoxia regulates FLT3 expression and biology in AML
Microenvironmental Hypoxia regulates FLT3 expression and biology in AML
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase constitutively expressed by acute myeloid leukaemia (AML) blasts. In addition, 25% of AML patients harbour a FLT3-ITD mutation, associated with inferior outcome due to increased relapse rate. Relapse might be propagated by interactions between AML blasts and the bone marrow microenviro...
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Full title
Microenvironmental Hypoxia regulates FLT3 expression and biology in AML
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4663471
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4663471
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep17550
