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A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylati...

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylati...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4664366

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

About this item

Full title

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (47), p.14623-14628

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Regulated shedding of the ectodomain of cell membrane proteins by proteases is a common process that releases the extracellular domain from the cell and activates cell signaling. Ectodomain shedding occurs in the immediate extracellular juxtamembrane region, which is also where O-glycosylation is often found and examples of crosstalk between sheddi...

Alternative Titles

Full title

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4664366

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4664366

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1511175112

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