Blockade of Tolerance to Morphine but not to κ Opioids by a Nitric Oxide Synthase Inhibitor
Blockade of Tolerance to Morphine but not to κ Opioids by a Nitric Oxide Synthase Inhibitor
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Author / Creator
Publisher
Washington, DC: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publication information
Publisher
Washington, DC: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
The nitric oxide synthase inhibitor NG-nitro-L-arginine (NO2Arg) blocks morphine tolerance in mice. After implantation of morphine pellets the analgesic response decreases from 100% on the first day to 0% on the third. Coadministration of NO2Arg along with the pellets markedly retards the development of tolerance; 60% of mice are analgesic after 3...
Alternative Titles
Full title
Blockade of Tolerance to Morphine but not to κ Opioids by a Nitric Oxide Synthase Inhibitor
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_46675
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_46675
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.90.11.5162
