Content and activity of human liver microsomal protein and prediction of individual hepatic clearanc...
Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo
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Author / Creator
Zhang, Haifeng , Gao, Na , Tian, Xin , Liu, Tingting , Fang, Yan , Zhou, Jun , Wen, Qiang , Xu, Binbin , Qi, Bing , Gao, Jie , Li, Hongmeng , Jia, Linjing and Qiao, Hailing
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The lack of information concerning individual variation in content and activity of human liver microsomal protein is one of the most important obstacles for designing personalized medicines. We demonstrated that the mean value of microsomal protein per gram of liver (MPPGL) was 39.46 mg/g in 128 human livers and up to 19-fold individual variations...
Alternative Titles
Full title
Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4669488
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4669488
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep17671
