REV7 counteracts DNA double-strand break resection and impacts PARP inhibition
REV7 counteracts DNA double-strand break resection and impacts PARP inhibition
About this item
Full title
Author / Creator
Xu, Guotai , Chapman, J. Ross , Brandsma, Inger , Yuan, Jingsong , Mistrik, Martin , Bouwman, Peter , Bartkova, Jirina , Gogola, Ewa , Warmerdam, Daniël , Barazas, Marco , Jaspers, Janneke E. , Watanabe, Kenji , Pieterse, Mark , Kersbergen, Ariena , Sol, Wendy , Celie, Patrick H. N. , Schouten, Philip C. , van den Broek, Bram , Salman, Ahmed , Nieuwland, Marja , de Rink, Iris , de Ronde, Jorma , Jalink, Kees , Boulton, Simon J. , Chen, Junjie , van Gent, Dik C. , Bartek, Jiri , Jonkers, Jos , Borst, Piet and Rottenberg, Sven
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
Error-free repair of DNA double-strand breaks (DSB) is achieved by homologous recombination (HR), and BRCA1 is an important factor for this repair pathway
1
. In the absence of BRCA1-mediated HR, administration of PARP inhibitors induces synthetic lethality of tumor cells of patients with breast or ovarian cancers
2
,
3
. Despite...
Alternative Titles
Full title
REV7 counteracts DNA double-strand break resection and impacts PARP inhibition
Authors, Artists and Contributors
Author / Creator
Chapman, J. Ross
Brandsma, Inger
Yuan, Jingsong
Mistrik, Martin
Bouwman, Peter
Bartkova, Jirina
Gogola, Ewa
Warmerdam, Daniël
Barazas, Marco
Jaspers, Janneke E.
Watanabe, Kenji
Pieterse, Mark
Kersbergen, Ariena
Sol, Wendy
Celie, Patrick H. N.
Schouten, Philip C.
van den Broek, Bram
Salman, Ahmed
Nieuwland, Marja
de Rink, Iris
de Ronde, Jorma
Jalink, Kees
Boulton, Simon J.
Chen, Junjie
van Gent, Dik C.
Bartek, Jiri
Jonkers, Jos
Borst, Piet
Rottenberg, Sven
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4671316
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4671316
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14328
