Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons
About this item
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Author / Creator
Jiang, Houbo , Xu, Zhimin , Zhong, Ping , Ren, Yong , Liang, Gaoyang , Schilling, Haley A. , Hu, Zihua , Zhang, Yi , Wang, Xiaomin , Chen, Shengdi , Yan, Zhen and Feng, Jian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The direct conversion of fibroblasts to induced dopaminergic (iDA) neurons and other cell types demonstrates the plasticity of cell fate. The low efficiency of these relatively fast conversions suggests that kinetic barriers exist to safeguard cell-type identity. Here we show that suppression of p53, in conjunction with cell cycle arrest at G1 and...
Alternative Titles
Full title
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4672381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4672381
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10100
