Acute loss of TET function results in aggressive myeloid cancer in mice
Acute loss of TET function results in aggressive myeloid cancer in mice
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant...
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Full title
Acute loss of TET function results in aggressive myeloid cancer in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4674670
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4674670
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10071
