TRAIL-R2 Superoligomerization Induced by Human Monoclonal Agonistic Antibody KMTR2
TRAIL-R2 Superoligomerization Induced by Human Monoclonal Agonistic Antibody KMTR2
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The fully human monoclonal antibody KMTR2 acts as a strong direct agonist for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2), which is capable of inducing apoptotic cell death without cross-linking. To investigate the mechanism of direct agonistic activity induced by KMTR2, the crystal structure of the extrace...
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Full title
TRAIL-R2 Superoligomerization Induced by Human Monoclonal Agonistic Antibody KMTR2
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4682084
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4682084
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep17936
