Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered ora...
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Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4682112
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4682112
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10166
