A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Crystallographic analysis depicting the interaction of the kinase inhibitor SCH772984 with ERK1/2 reveals a unique binding pocket distinct from off-targets such as haspin and is associated with slow binding kinetics and prolonged inhibitory activity.
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partn...
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Full title
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4687050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4687050
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1629
