A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutation...
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synthetically lethal in β-catenin-activated cancer cells would provide new targets for therapeutic drug design.
We transfected the parental Hu...
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Full title
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4696130
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4696130
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ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-015-2037-8
