Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
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Author / Creator
Zhang, Qian , Zhao, Kai , Shen, Qicong , Han, Yanmei , Gu, Yan , Li, Xia , Zhao, Dezhi , Liu, Yiqi , Wang, Chunmei , Zhang, Xiang , Su, Xiaoping , Liu, Juan , Ge, Wei , Levine, Ross L. , Li, Nan and Cao, Xuetao
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The Tet2 enzyme, which catalyses
de novo
hydroxymethylation of DNA, is shown here to act as a transcriptional repressor by recruiting the histone deacetylase Hdac2 to the
Il6
promoter in the course of resolution of the LPS-induced inflammatory response.
Anti-inflammatory action of Tet2
The regulation of immunity and inflammation b...
Alternative Titles
Full title
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4697747
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4697747
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature15252
