Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate...
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice
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Full title
Author / Creator
Thoonen, Robrecht , Cauwels, Anje , Decaluwe, Kelly , Geschka, Sandra , Tainsh, Robert E. , Delanghe, Joris , Hochepied, Tino , De Cauwer, Lode , Rogge, Elke , Voet, Sofie , Sips, Patrick , Karas, Richard H. , Bloch, Kenneth D. , Vuylsteke, Marnik , Stasch, Johannes-Peter , Van de Voorde, Johan , Buys, Emmanuel S. and Brouckaert, Peter
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. Apo-sGC mice are viable and develop hypertension. The haemodynamic effects of NO are abolished, but...
Alternative Titles
Full title
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice
Authors, Artists and Contributors
Author / Creator
Cauwels, Anje
Decaluwe, Kelly
Geschka, Sandra
Tainsh, Robert E.
Delanghe, Joris
Hochepied, Tino
De Cauwer, Lode
Rogge, Elke
Voet, Sofie
Sips, Patrick
Karas, Richard H.
Bloch, Kenneth D.
Vuylsteke, Marnik
Stasch, Johannes-Peter
Van de Voorde, Johan
Buys, Emmanuel S.
Brouckaert, Peter
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4699393
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4699393
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms9482
