Individual intestinal symbionts induce a distinct population of RORγ+regulatory T cells
Individual intestinal symbionts induce a distinct population of RORγ+regulatory T cells
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Author / Creator
Sefik, Esen , Geva-Zatorsky, Naama , Oh, Sungwhan , Konnikova, Liza , Zemmour, David , McGuire, Abigail Manson , Burzyn, Dalia , Ortiz-Lopez, Adriana , Lobera, Mercedes , Yang, Jianfei , Ghosh, Shomir , Earl, Ashlee , Snapper, Scott B. , Jupp, Ray , Kasper, Dennis , Mathis, Diane and Benoist, Christophe
Publisher
American Association for the Advancement of Science
Journal title
Language
English
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Publisher
American Association for the Advancement of Science
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Scope and Contents
Contents
T regulatory cells that express the transcription factor Foxp3 (Foxp3+ Tregs) promote tissue homeostasis in several settings. We now report that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses. This induction–which we find to map to a broad, but speci...
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Full title
Individual intestinal symbionts induce a distinct population of RORγ+regulatory T cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700932
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700932
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaa9420
