Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule reso...
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA. Using single-molecule FRET, we show that AID binds to transcribed dsDNA and translocates unidirecti...
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Full title
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4703863
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4703863
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10209
