Phospholipases C and A2 control lysosome-mediated IL-1β secretion: Implications for inflammatory pro...
Phospholipases C and A2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes
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Publisher
United States: National Acad Sciences
Journal title
Language
English
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Publisher
United States: National Acad Sciences
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Scope and Contents
Contents
Blocking the activity of IL-1β has entered the clinical arena of treating autoimmune diseases. However, a successful outcome of this approach requires a clear definition of the mechanisms controlling IL-1β release. These are still unclear as IL-1β, lacking a secretory signal peptide, follows a nonclassical pathway of secretion. Here, we analyze the...
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Full title
Phospholipases C and A2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_470745
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_470745
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0308558101
